Accession | TIGR01302 |
Name | IMP_dehydrog |
Function | inosine-5'-monophosphate dehydrogenase |
Gene Symbol | guaB |
Trusted Cutoff | 481.50 |
Domain Trusted Cutoff | 481.50 |
Noise Cutoff | 303.25 |
Domain Noise Cutoff | 303.25 |
Isology Type | equivalog |
EC Number | 1.1.1.205 |
HMM Length | 450 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | Purine ribonucleotide biosynthesis |
Gene Ontology Term | GO:0003938: IMP dehydrogenase activity molecular_function |
| GO:0009152: purine ribonucleotide biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Jul 6 2001 12:51PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM describes IMP dehydrogenase, an enzyme of GMP biosynthesis. This form contains two CBS domains.
This HMM describes a rather tightly conserved cluster of IMP dehydrogenase sequences, many of which are characterized. The model excludes two related families of proteins proposed also to be IMP dehydrogenases, but without characterized members. These are related families are the subject of separate models. |
References | DR; PFAM; PF00571; CBS (two copies)
DR; PFAM; PF00478; IMPDH_C
DR; PFAM; PF01574; IMPDH_N
DR; EXPERIMENTAL; SP|P50097; Tritrichomonas foetus
DR; EXPERIMENTAL; SP|P50099; Streptococcus pyogenes
DR; EXPERIMENTAL; GP|146275; Homo sapiens |
Genome Property | GenProp0697: guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP) (HMM) |