Accession | TIGR01290 |
Name | nifB |
Function | nitrogenase cofactor biosynthesis protein NifB |
Gene Symbol | nifB |
Trusted Cutoff | 343.65 |
Domain Trusted Cutoff | 343.65 |
Noise Cutoff | 222.20 |
Domain Noise Cutoff | 222.20 |
Isology Type | equivalog |
HMM Length | 441 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Other |
Gene Ontology Term | GO:0009399: nitrogen fixation biological_process |
| GO:0051186: cofactor metabolic process biological_process |
Author | Haft DH |
Entry Date | Jun 26 2001 3:50PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM describes NifB, a protein required for the biosynthesis of the iron-molybdenum (or iron-vanadium) cofactor used by the nitrogen-fixing enzyme nitrogenase. NifB belongs to the radical SAM family, and the FeMo cluster biosynthesis process requires S-adenosylmethionine. Archaeal homologs lack the most C-terminal region and score between the trusted and noise cutoffs of this model. |
References | RN [1]
RM 7592933
RT Incorporation of iron and sulfur from NifB cofactor into the iron-molybdenum cofactor of dinitrogenase.
RA Allen RM, Chatterjee R, Ludden PW, Shah VK
RL J Biol Chem 1995 Nov 10;270(45):26890-6
RN [2]
RM 10364262
RT A vanadium and iron cluster accumulates on VnfX during iron-vanadium-cofactor synthesis for the vanadium nitrogenase in Azotobacter vinelandii.
RA Ruttimann-Johnson C, Staples CR, Rangaraj P, Shah VK, Ludden PW
RL J Biol Chem 1999 Jun 18;274(25):18087-92
RN [3]
RM PMID:16567617
RT NifB-dependent in vitro synthesis of the iron-molybdenum cofactor of nitrogenase.
RA Curatti L, Ludden PW, Rubio LM
RL Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5297-301. |
Genome Property | GenProp0029: nitrogen fixation (HMM) |