| Comment | This family includes elongator complex protein 3 (ELP3) from eukaryotes and related proteins from other lineages. ELP3 is a component of the RNA polymerase II holoenzyme. It has an N-terminal radical SAM domain and C-terminal GNAT acetyltransferase domain. Members of this family are found in eukaryotes, archaea, and a few bacteria (e.g. Atopobium sp). The activity discovered first was an acetyltransferase modification at the N-termini of all four core histones, shown in vitro in eukaryotes. More recently, the radical SAM domain was shown to play a role in zygotic paternal genome demethylation. Family TIGR01212, widespread in prokaryotes, lacks the GNAT acetyltransferase domain but shares extensive sequence similarity with this family (TIGR01211). |
| References | DR COGS; COG1243
RN [1]
RM PMID:10445034
RT A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme.
RA Wittschieben BO, Otero G, de Bizemont T, Fellows J, Erdjument-Bromage H, Ohba R, Li Y, Allis CD, Tempst P, Svejstrup JQ
RL Mol Cell. 1999 Jul;4(1):123-8.
RN [2]
RM PMID:20054296
RT A role for the elongator complex in zygotic paternal genome demethylation.
RA Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y
RL Nature. 2010 Jan 28;463(7280):554-8. doi: 10.1038/nature08732. |
