Accession | TIGR01203 |
Name | HGPRTase |
Function | hypoxanthine phosphoribosyltransferase |
Gene Symbol | hpt |
Trusted Cutoff | 150.00 |
Domain Trusted Cutoff | 150.00 |
Noise Cutoff | 62.10 |
Domain Noise Cutoff | 62.10 |
Isology Type | equivalog |
EC Number | 2.4.2.8 |
HMM Length | 167 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | Salvage of nucleosides and nucleotides |
Gene Ontology Term | GO:0004422: hypoxanthine phosphoribosyltransferase activity molecular_function |
| GO:0006166: purine ribonucleoside salvage biological_process |
Author | Haft DH |
Entry Date | Mar 15 2001 8:52AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Alternate name: hypoxanthine-guanine phosphoribosyltransferase.
Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. |
References | RM 9521670
RT
A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine.
RA Lee CC, Craig SP, Eakin AE
RL Biochemistry 1998 Mar 10;37(10):3491-8 |