Accession | TIGR01128 |
Name | holA |
Function | DNA polymerase III, delta subunit |
Gene Symbol | holA |
Trusted Cutoff | 94.95 |
Domain Trusted Cutoff | 94.95 |
Noise Cutoff | 65.15 |
Domain Noise Cutoff | 65.15 |
Isology Type | equivalog |
EC Number | 2.7.7.7 |
HMM Length | 314 |
Mainrole Category | DNA metabolism |
Subrole Category | DNA replication, recombination, and repair |
Gene Ontology Term | GO:0003887: DNA-directed DNA polymerase activity molecular_function |
| GO:0006260: DNA replication biological_process |
| GO:0009360: DNA polymerase III complex cellular_component |
Author | Durkin S, Haft DH |
Entry Date | Jan 17 2001 12:30PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX.
The delta, delta prime, gamma, chi and psi subunits form the
gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta
subunit around DNA forming a DNA sliding clamp. |
References | RN [1]
RM 8505303
RT DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.
RA Dong Z, Onrust R, Skangalis M, O'Donnell M
RL J Biol Chem 1993 Jun 5;268(16):11758-65
RN [2]
RM 8505304
RT DNA polymerase III accessory proteins. II. Characterization of delta and delta'.
RA Onrust R, O'Donnell M
RL J Biol Chem 1993 Jun 5;268(16):11766-72 |
Genome Property | GenProp0263: DNA polymerase III, bacterial (HMM) |