Accession | TIGR01056 |
Name | topB |
Function | DNA topoisomerase III |
Gene Symbol | topB |
Trusted Cutoff | 515.75 |
Domain Trusted Cutoff | 515.75 |
Noise Cutoff | 356.40 |
Domain Noise Cutoff | 356.40 |
Isology Type | subfamily |
EC Number | 5.99.1.2 |
HMM Length | 706 |
Mainrole Category | DNA metabolism |
Subrole Category | DNA replication, recombination, and repair |
Gene Ontology Term | GO:0003677: DNA binding molecular_function |
| GO:0003917: DNA topoisomerase type I activity molecular_function |
| GO:0006265: DNA topological change biological_process |
Author | Ujwal ML, Haft DH |
Entry Date | Nov 30 2000 11:09AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. |
References | RM 97382294
RT The traE gene of plasmid RP4 encodes a homologue of Escherichia coli DNA topoisomerase III.
RA Li Z, Hiasa H, Kumar U, DiGate RJ
RL J Biol Chem 1997 Aug 1;272(31):19582-7 |