| Accession | TIGR00957 |
| Name | MRP_assoc_pro |
| Function | multi drug resistance-associated protein (MRP) |
| Trusted Cutoff | 1470.00 |
| Domain Trusted Cutoff | 1470.00 |
| Noise Cutoff | 1470.00 |
| Domain Noise Cutoff | 1470.00 |
| Isology Type | equivalog |
| HMM Length | 1522 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0006855: drug transmembrane transport biological_process |
| | GO:0015559: multidrug efflux pump activity molecular_function |
| | GO:0042493: response to drug biological_process |
| Author | Ujwal ML, Loftus BJ, Paulsen IT |
| Entry Date | Sep 26 2000 4:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. |
| References | RM 93088080
RT Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
RA Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G.
RL Science 258:1650-1654(1992). |
