Accession | TIGR00917 |
Name | 2A060601 |
Function | Niemann-Pick C type protein family |
Trusted Cutoff | 1016.50 |
Domain Trusted Cutoff | 1016.50 |
Noise Cutoff | 1004.70 |
Domain Noise Cutoff | 1004.70 |
Isology Type | subfamily |
HMM Length | 1204 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Other |
Author | Loftus BJ, Ujwal ML, Paulsen IT |
Entry Date | Sep 13 2000 10:27AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. |