| Accession | TIGR00872 |
| Name | gnd_rel |
| Function | 6-phosphogluconate dehydrogenase (decarboxylating) |
| Gene Symbol | gnd |
| Trusted Cutoff | 297.20 |
| Domain Trusted Cutoff | 297.20 |
| Noise Cutoff | 267.50 |
| Domain Noise Cutoff | 267.50 |
| Isology Type | equivalog |
| EC Number | 1.1.1.44 |
| HMM Length | 299 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Pentose phosphate pathway |
| Gene Ontology Term | GO:0004616: phosphogluconate dehydrogenase (decarboxylating) activity molecular_function |
| | GO:0006098: pentose-phosphate shunt biological_process |
| Author | Haft DH |
| Entry Date | Sep 7 2000 4:18PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle[1]. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. |
| References | RN [1]
RM PMID: 10658669
RT Analysis of two formaldehyde oxidation pathways in Methylobacillus flagellatus KT, a ribulose monophosphate cycle methylotroph
RA Chistoserdova L, Gomelsky L, Vorholt JA, Gomelsky M, Tsygankov YD, Lidstrom ME
RL Microbiology. 2000 Jan;146 ( Pt 1):233-8 |
| Genome Property | GenProp0120: pentose phosphate cycle (HMM) |
