Accession | TIGR00770 |
Name | Dcu |
Function | transporter, anaerobic C4-dicarboxylate uptake (Dcu) family |
Trusted Cutoff | 331.35 |
Domain Trusted Cutoff | 331.35 |
Noise Cutoff | 248.70 |
Domain Noise Cutoff | 248.70 |
Isology Type | subfamily |
HMM Length | 430 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Carbohydrates, organic alcohols, and acids |
Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| GO:0015556: C4-dicarboxylate transmembrane transporter activity molecular_function |
| GO:0015740: C4-dicarboxylate transport biological_process |
Author | Paulsen IT, Saier MH, Loftus BJ |
Entry Date | Jul 7 2000 1:40PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | These proteins are members of th C4-Dicarboxylate Uptake (Dcu) Family (TC 2.A.13). Most proteins in this family have 12 GES predicted transmembrane regions; however one member has 10 experimentally determined transmembrane regions with both the N- and C-termini localized to the periplasm. The two Escherichia coli proteins, DcuA and DcuB, transport aspartate, malate, fumarate and succinate, and function as antiporters with any two of these substrates. Since DcuA is encoded in an operon with the gene for aspartase, and DcuB is encoded in an operon with the gene for fumarase, their physiological functions may be to catalyze aspartate:fumarate and fumarate:malate exchange during the anaerobic utilization of aspartate and fumarate, respectively. |
References | SE Ipaulsen
DR URL; http://www-biology.ucsd.edu/~msaier/transport/2_A_13.html |