Accession | TIGR00768 |
Name | rimK_fam |
Function | alpha-L-glutamate ligase, RimK family |
Trusted Cutoff | 143.40 |
Domain Trusted Cutoff | 143.40 |
Noise Cutoff | 100.80 |
Domain Noise Cutoff | 100.80 |
Isology Type | subfamily |
EC Number | 6.3.2.- |
HMM Length | 276 |
Author | Haft DH |
Entry Date | Jun 13 2000 5:57PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001). |
References | AL clustalw
DR EXPERIMENTAL; EGAD|6445|EC0852; Escherichia coli
RN [1]
RM 89364710
RT Characterization of the gene rimK responsible for the addition of glutamic acid residues to the C-terminus of ribosomal protein S6 in Escherichia coli K12.
RA Kang WK, Icho T, Isono S, Kitakawa M, Isono K
RL Mol Gen Genet 1989 Jun;217(2-3):281-8
RN [2]
RM 98078575
RT A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity.
RA Galperin MY, Koonin EV
RL Protein Sci 1997 Dec;6(12):2639-43
RN [3]
RT Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
RA Li H, Xu H, Graham DE, White RH.
RL Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9785-90
DR HAMAP; MF_01552; 114 of 117 |