Accession | TIGR00762 |
Name | DegV |
Function | EDD domain protein, DegV family |
Trusted Cutoff | 99.70 |
Domain Trusted Cutoff | 99.70 |
Noise Cutoff | 84.10 |
Domain Noise Cutoff | 84.10 |
Isology Type | domain |
HMM Length | 276 |
Mainrole Category | Unknown function |
Subrole Category | General |
Gene Ontology Term | GO:0005575: cellular_component cellular_component |
| GO:0008150: biological_process biological_process |
| GO:0016740: transferase activity molecular_function |
Author | Haft DH, Dodson RJ |
Entry Date | Jun 13 2000 5:57PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. |
References | RN [1]
RM PMID:15632288
RT EDD, a novel phosphotransferase domain common to mannose transporter EIIA, dihydroxyacetone kinase, and DegV.
RA Kinch LN, Cheek S, Grishin NV
RL Protein Sci. 2005 Feb;14(2):360-7. |