| Accession | TIGR00758 |
| Name | UDG_fam4 |
| Function | uracil-DNA glycosylase, family 4 |
| Trusted Cutoff | 125.30 |
| Domain Trusted Cutoff | 125.30 |
| Noise Cutoff | 27.10 |
| Domain Noise Cutoff | 27.10 |
| Isology Type | subfamily |
| EC Number | 3.2.2.- |
| HMM Length | 173 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0004844: uracil DNA N-glycosylase activity molecular_function |
| | GO:0006281: DNA repair biological_process |
| Author | Haft DH, Dodson RJ |
| Entry Date | Jun 13 2000 5:57PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This well-conserved family of proteins is about 200 residues in length and homologous to the N-terminus of the DNA polymerase of phage SPO1 of Bacillus subtilis. The member from Thermus thermophilus HB8 is known to act as uracil-DNA glycosylase, an enzyme of DNA base excision repair. Its appearance as a domain of phage DNA polymerases could be consistent with uracil-DNA glycosylase activity. |
| References | RN [1]
RM 14556741
RT Crystal structure of a family 4 uracil-DNA glycosylase from Thermus thermophilus HB8.
RA Hoseki J, Okamoto A, Masui R, Shibata T, Inoue Y, Yokoyama S, Kuramitsu S.
RL J Mol Biol. 2003 Oct 24;333(3):515-26.
RN [2]
RM 92380475
RT The DNA polymerase-encoding gene of Bacillus subtilis bacteriophage SPO1
RA Scarlato V, Gargano S
RL Gene 1992 Sep 1;118(1):109-13 |
