| Accession | TIGR00733 |
| Name | TIGR00733 |
| Function | oligopeptide transporter, OPT family |
| Trusted Cutoff | 182.50 |
| Domain Trusted Cutoff | 182.50 |
| Noise Cutoff | 77.15 |
| Domain Noise Cutoff | 77.15 |
| Isology Type | equivalog |
| HMM Length | 589 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Amino acids, peptides and amines |
| Gene Ontology Term | GO:0006857: oligopeptide transport biological_process |
| | GO:0015198: oligopeptide transporter activity molecular_function |
| | GO:0016020: membrane cellular_component |
| Author | Haft DH |
| Entry Date | Feb 22 2000 11:31AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein represents a small family of integral membrane proteins from Gram-negative bacteria, a Gram-positive bacteria, and an archaeal species. Members of this family contain 15 to 18 GES predicted transmembrane regions, and this family has extensive homology to a family of yeast tetrapeptide transporters, including isp4 (Schizosaccharomyces pombe) and Opt1 (Candida albicans). EspB, an apparent equivalog from Myxococcus xanthus, shares an operon with a two component system regulatory protein, and is required for the normal timing of sporulation after the aggregation of cells. This is consistent with a role in transporting oligopeptides as signals across the membrane. |
| References | RN [1]
RM 20032045
RT Sporulation timing in Myxococcus xanthus is controlled by the espAB locus.
RA Cho K, Zusman DR
RL Mol Microbiol 1999 Nov;34(4):714-25
RN [2]
RM 98305694
RT Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters.
RA Lubkowitz MA, Barnes D, Breslav M, Burchfield A, Naider F, Becker JM
RL Mol Microbiol 1998 May;28(4):729-41 |
