| Accession | TIGR00583 |
| Name | mre11 |
| Function | DNA repair protein (mre11) |
| Trusted Cutoff | 434.60 |
| Domain Trusted Cutoff | 434.60 |
| Noise Cutoff | 203.25 |
| Domain Noise Cutoff | 203.25 |
| Isology Type | equivalog |
| HMM Length | 405 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0004519: endonuclease activity molecular_function |
| | GO:0006281: DNA repair biological_process |
| | GO:0006303: double-strand break repair via nonhomologous end joining biological_process |
| | GO:0007004: telomere maintenance via telomerase biological_process |
| | GO:0008408: 3'-5' exonuclease activity molecular_function |
| Author | Loftus BJ, Eisen JA |
| Entry Date | Oct 19 1999 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | All proteins in this family for which functions are known are subunits of a nuclease complex made up of multiple proteins including MRE11 and RAD50 homologs. The functions of this nuclease complex include recombinational repair and non-homolgous end joining. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The proteins in this family are distantly related to proteins in the SbcCD complex of bacteria. |
| References | A2 hmmalign
GA hmmsearch
DR EGAD; 55138;
DR SWISSPROT; P32829;
RM 95309669; |
