HMM Summary Page: TIGR00294
| Accession | TIGR00294 |
| Name | TIGR00294 |
| Function | GTP cyclohydrolase |
| Trusted Cutoff | 100.35 |
| Domain Trusted Cutoff | 100.35 |
| Noise Cutoff | 96.10 |
| Domain Noise Cutoff | 96.10 |
| Isology Type | hypoth_equivalog |
| EC Number | 3.5.4.- |
| HMM Length | 308 |
| Mainrole Category | Hypothetical proteins |
| Subrole Category | Conserved |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:05PM |
| Last Modified | Aug 12 2012 8:47PM |
| Comment | This family includes type I GTP cyclohydrolases involved in methanopterin in archaea (MptA) and de novo tetrahydrofolate biosynthesis in bacteria (FolE2). |
| References | RN [1] RM PMID:17497938 RT Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii. RA Grochowski LL, Xu H, Leung K, White RH RL Biochemistry. 2007 Jun 5;46(22):6658-67. RN [2] RM PMID:17032654 RT Discovery of a new prokaryotic type I GTP cyclohydrolase family. RA El Yacoubi B, Bonnett S, Anderson JN, Swairjo MA, Iwata-Reuyl D, de Crecy-Lagard V RL J Biol Chem. 2006 Dec 8;281(49):37586-93. DR HAMAP; MF_01527; 85 of 167 |