| Accession | TIGR00160 |
| Name | MGSA |
| Function | methylglyoxal synthase |
| Gene Symbol | mgsA |
| Trusted Cutoff | 146.90 |
| Domain Trusted Cutoff | 146.90 |
| Noise Cutoff | 71.55 |
| Domain Noise Cutoff | 71.55 |
| Isology Type | equivalog |
| EC Number | 4.2.3.3 |
| HMM Length | 143 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0006007: glucose catabolic process biological_process |
| | GO:0008929: methylglyoxal synthase activity molecular_function |
| | GO:0019242: methylglyoxal biosynthetic process biological_process |
| Author | Richardson DL, Haft DH |
| Entry Date | Apr 20 1999 2:04PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Methylglyoxal synthase (MGS) generates methylglyoxal (MG), a toxic metabolite (that may also be a regulatory metabolite and) that is detoxified, prinicipally, through a pathway involving glutathione and glyoxylase I. Totemeyer, et al. (MUID:98149311) propose that, during a loss of control over carbon flux, with accumulation of phosphorylated sugars and depletion of phosphate, as might happen during a rapid shift to a richer medium, MGS aids the cell by converting some dihydroxyacetone phosphate (DHAP) to MG and phosphate. This is therefore an alternative to triosephosphate isomerase and the remainder of the glycolytic pathway for the disposal of DHAP during the stress of a sudden increase in available sugars. |
| References | DR ECOCYC; EG12307; mgsA;
RM 98149311
RT From famine to feast: the role of methylglyoxal production in Escherichia coli.
RA Totemeyer S, Booth NA, Nichols WW, Dunbar B, Booth IR
RL Mol Microbiol 1998 Feb;27(3):553-62
SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00549; 124 of 127 |
