HMM Summary Page: TIGR00139
| Accession | TIGR00139 |
| Name | h_aconitase |
| Function | homoaconitase |
| Gene Symbol | lysF |
| Trusted Cutoff | 529.90 |
| Domain Trusted Cutoff | 529.90 |
| Noise Cutoff | 315.30 |
| Domain Noise Cutoff | 315.30 |
| Isology Type | equivalog |
| EC Number | 4.2.1.36 |
| HMM Length | 709 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aspartate family |
| Gene Ontology Term | GO:0004409: homoaconitate hydratase activity molecular_function |
| GO:0009085: lysine biosynthetic process biological_process | |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:07PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Homoaconitase is known only as a fungal enzyme from two species, where it is part of an unusual lysine biosynthesis pathway. Because this HMM is based on just two sequences from a narrow taxonomic range, it may not recognize distant orthologs, should any exist. Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures, but 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble leuC and leuD over their lengths but are even closer to the respective domains of homoaconitase, and their identity is uncertain. |
| References | A2 hmmalign RL Microbiology 1996 Feb;142( Pt 2):389-400 SE TIGR GA hmmls AL clustalw BD build_dir/0250 |