Accession | TIGR00084 |
Name | ruvA |
Function | Holliday junction DNA helicase RuvA |
Gene Symbol | ruvA |
Trusted Cutoff | 116.45 |
Domain Trusted Cutoff | 116.45 |
Noise Cutoff | 81.50 |
Domain Noise Cutoff | 81.50 |
Isology Type | equivalog |
EC Number | 3.6.4.12 |
HMM Length | 192 |
Mainrole Category | DNA metabolism |
Subrole Category | DNA replication, recombination, and repair |
Gene Ontology Term | GO:0006310: DNA recombination biological_process |
| GO:0009378: four-way junction helicase activity molecular_function |
| GO:0009379: Holliday junction helicase complex cellular_component |
Author | Richardson DL, Haft DH |
Entry Date | Apr 20 1999 2:09PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. |
References | SE TIGR
GA hmmls
RN [1]
RM 98105106
RT Processing of recombination intermediates by the RuvABC proteins.
RA West SC
RL Annu Rev Genet 1997;31:213-44
RN [2]
RM 97199382
DR HAMAP; MF_00031; 463 of 486 |
Genome Property | GenProp0198: ruvABC Holliday junction complex (HMM) |