Accession | TIGR00040 |
Name | yfcE |
Function | phosphodiesterase, MJ0936 family |
Trusted Cutoff | 56.25 |
Domain Trusted Cutoff | 56.25 |
Noise Cutoff | 40.05 |
Domain Noise Cutoff | 40.05 |
Isology Type | subfamily |
EC Number | 3.1.-.- |
HMM Length | 158 |
Mainrole Category | Unknown function |
Subrole Category | Enzymes of unknown specificity |
Gene Ontology Term | GO:0016788: hydrolase activity, acting on ester bonds molecular_function |
Author | Haft DH, Richardson DL |
Entry Date | Apr 20 1999 2:04PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this largely uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterized archaeal putative phosphoesterases described by TIGR00024. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanococcus jannaschii, was shown (PMID:15128743) to act on model phosphodiesterase substrates; a divalent cation was required. |
References | DR PROSITE; PDOC00976;
SE TIGR
RM 15128743
RT Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii.
RA Chen S, Yakunin AF, Kuznetsova E, Busso D, Pufan R, Proudfoot M, Kim R, Kim SH.
RL J Biol Chem. 2004 May 5 [Epub ahead of print] |