Accession | TIGR00014 |
Name | arsC |
Function | arsenate reductase (glutaredoxin) |
Gene Symbol | arsC |
Trusted Cutoff | 106.05 |
Domain Trusted Cutoff | 106.05 |
Noise Cutoff | 61.55 |
Domain Noise Cutoff | 61.55 |
Isology Type | equivalog |
EC Number | 1.20.4.1 |
HMM Length | 114 |
Mainrole Category | Cellular processes |
Subrole Category | Detoxification |
Gene Ontology Term | GO:0008794: arsenate reductase (glutaredoxin) activity molecular_function |
| GO:0046685: response to arsenic-containing substance biological_process |
Author | Haft DH, Dodson RJ, Richardson DL |
Entry Date | Apr 20 1999 2:06PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam PF03960. This clade is almost completely restricted to the Proteobacteria.
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is
composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. |
References | A2 hmmalign
DR Medline; 1704144;
RA Rosen, BP
RT The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.
RL Res Microbiol 141(3):336-341.
SE TIGR
GA search with previous arsC model
AL hmma on previous arsC model
BD build_dir/0016 |
Genome Property | GenProp0474: arsenical resistance system (HMM-CLUST) |