Accession | GenProp1079 |
Name | Lpt lipopolysaccharide export transenvelope protein complex |
Type | SYSTEM |
Description | Lipopolysaccharide transport(Lpt) as it occurs in E. coli requires a complex with seven essential genes. LptBCFG spans the inner membrane, with LptBFG being an ABC transporter. LptA is periplasmic, and LptDE is in the outer membrane. |
JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
Literature References | [ 1 ]Villa R, Martorana AM, Okuda S, Gourlay LJ, Nardini M, Sperandeo P, Deho G, Bolognesi M, Kahne D, Polissi A The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains. J Bacteriol. 2013 Jan 4. PMID 23292770 [ 2 ]Bos MP, Tommassen J The LptD chaperone LptE is not directly involved in lipopolysaccharide transport in Neisseria meningitidis. J Biol Chem. 2011 Aug 19;286(33):28688-96. PMID 21705335 |
|
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|
LPS transport periplasmic protein LptA | lptA | YES | TIGR03002 (HMM): lipopolysaccharide transport periplasmic protein LptA | |
LPS export ABC transporter ATP-binding protein | lptB | YES | TIGR04406 (HMM): LPS export ABC transporter ATP-binding protein | |
lipopolysaccharide export protein LptC | lptC | YES | PF06835 (HMM): Lipopolysaccharide-assembly, LptC-related TIGR04409 (HMM): LPS export ABC transporter periplasmic protein LptC | |
LPS assembly OM complex protein LptD | lptD | YES | PF04453 (HMM): lipopolysaccharide transport system LptD protein | |
LPS assembly OM complex protein LptE | lptE | YES | PF04390 (HMM): LPS export system outer membrane protein LptE | |
LPS export ABC permease LptF | lptF | YES | TIGR04407 (HMM): LPS export ABC transporter permease LptF | |
LPS export ABC permease LptG | lptG | YES | TIGR04408 (HMM): LPS export ABC transporter permease LptG | |