Genome Property Definition Page

Accession

GenProp1060

Name

tRNA N6-threonylcarbamoyladenosine modification

Type

SYSTEM

Description

E. coli genes ygjD, yeaZ, yrdC (rimN) and yjeE encode proteins involved in a universal tRNA modification, N6-threonylcarbamoyladenosine.

JCVI Role

tRNA and rRNA base modification

Parent Property

GenProp0819: RNA metabolism

Literature References

[ 1 ]Hashimoto C, Sakaguchi K, Taniguchi Y, Honda H, Oshima T, Ogasawara N, Kato J Effects on transcription of mutations in ygjD, yeaZ, and yjeE genes, which are involved in a universal tRNA modification in Escherichia coli. J Bacteriol. 2011 Nov;193(21):6075-9. PMID 21873492
[ 2 ]Deutsch C, El Yacoubi B, de Crecy-Lagard V, Iwata-Reuyl D Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside. J Biol Chem. 2012 Apr 20;287(17):13666-73. PMID 22378793

Gene Ontology Term

GO:0006400: tRNA modification (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
YeaZ protein	N6_YeaZ	YES	TIGR03725 (HMM): tRNA threonylcarbamoyl adenosine modification protein YeaZ	GO:0006400: tRNA modification
YgjD protein	N6_YgjD	YES	TIGR03723 (HMM): tRNA threonylcarbamoyl adenosine modification protein TsaD	GO:0006400: tRNA modification
YjeE protein	N6_YjeE	YES	TIGR00150 (HMM): tRNA threonylcarbamoyl adenosine modification protein YjeE	GO:0006400: tRNA modification
YrdC protein	N6_YrdC	YES	TIGR00057 (HMM): tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family	GO:0006400: tRNA modification

Parent Properties

Accession	Name
GenProp0819	RNA metabolism

Sibling Properties

Accession	Name
GenProp0258	tRNA aminoacylation
GenProp0262	RNA polymerase, bacterial
GenProp0482	6S RNA (eubacterial RNA polymerase regulator)
GenProp0677	queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0692	selenouridine-containing tRNA
GenProp0704	tRNA U34 carboxymethylaminomethyl modification
GenProp0898	RNA ligase/unknown protein pair
GenProp0948	RNA repair, Hen1/Pnkp system
GenProp1077	tRNA(Pro) cmo5UGG modification
GenProp1082	16S rRNA C1402 m(4)Cm modification