Accession | GenProp1046 |
Name | O153(Ec)-antigen biosynthesis |
Type | METAPATH |
Description | The E. coli O153 antigen is a linear pentasaccharide with the structure [->2)bDRibf(1->4)bDGal(1->4)aDGlcNAc(1->4)bDGal(1->3)aDGlcNAc(1->]. The four glycosidic linkages may be carried out by only three glycosyltransferases as the 2nd and 4th linkages only differ by position at which the transfer occurs (1->4, vs. 1->3), and only three genes are obviously glycosyltransferases in the biosynthetic cluster. On the other hand, there is one gene of unknown function which shares some homology with glycosyltransferases in the cluster, and there does not seem to be a need for any other function other than a fourth glycosyltransferase in the assembly of this O-antigen. |
JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
Literature References | [ 1 ]Ratnayake S, Weintraub A, Widmalm G Structural studies of the enterotoxigenic Escherichia coli (ETEC) O153 O-antigenic polysaccharide. Carbohydr Res. 1994 Dec 2;265(1):113-20. PMID 7834647 |
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