Genome Property Definition Page

AccessionGenProp1020
NameO91(Ec) antigen biosynthesis
TypeMETAPATH
DescriptionThe O91 antigen in E. coli is a linear pentasaccharide with the structure: [-->4)-a-D-Qui3NAcyl-(1-->4)-b-D-Gal-(1-->4)-b-D-GlcNAc-(1-->4)-b-D-GlcA6NGly-(1-->3)-b-D-GlcNAc-(1-->], where Acyl=(R)-3-hydroxybutyryl (Note that this is the structure as reported in the ECODAB database, whereas the original publication [1] has this permuted such that the b-D-galactose sugar is in the first position).
Literature References
[ 1 ]Kjellberg A, Weintraub A, Widmalm G  Structural determination and biosynthetic studies of the O-antigenic polysaccharide from the enterohemorrhagic Escherichia coli O91 using 13C-enrichment and NMR spectroscopy.  Biochemistry. 1999 Sep 21;38(38):12205-11.  PMID 10493787

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of 3-hydroxybutyramido-quinovoseQui3NAcyYESGenProp1021 (GENPROP): dTDP-3-hydroxybutyramidoquinovose (dTDP-D-Qui3NAcyl) biosynthesis from dTDP-3-aminoquinovose (dTDP-D-Qui3N)
b-D-GlcA6NGly-(1->3)-b-D-GlcNAc transferaseWbsAYES2867 (RULE_BASE)
a-D-Qui3NAcyl-(1->4)-b-D-Gal transferaseWbsEYES2869 (RULE_BASE)
b-D-GlcNAc-(1->4)-b-D-GlcA6NGly transferaseWbsFYES2872 (RULE_BASE)
b-D-Gal-(1->4)-b-D-GlcNAc transferaseWbsGYES2873 (RULE_BASE)
O91-specific transporter (flippase)wzx91YES2864 (RULE_BASE)
O91-specific polymerasewzy91YES2865 (RULE_BASE)