Genome Property Definition Page

AccessionGenProp0973
NameEnterobacterial common antigen (ECA)
TypeMETAPATH
DescriptionThe enterobacterial common antigen is composed of a repeating trisaccharide unit (Fuc4NAc-ManNAcA-GlcNAc). Fuc4NAC is 4-acetamido-4,6-dideoxy-D-galactose and ManNAcA is N-acetyl-D-mannosaminuronic acid. Polymerization and translocation from the cytoplasmic face to the periplasmic face of the plasma membrane is handled by an ECA-specific wzx/wzy/wzz system.

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of dTDP-4-acetamido-4,6-dideoxy-D-galactose (dTDP-Fuc4NAc)Fuc4NAcYESGenProp0972 (GENPROP): dTDP-4-acetamido-4,6-dideoxy-D-galactose (dTDP-Fuc4NAc) biosynthesis
source of Und-PP-GlcNAcInitYESGenProp0970 (GENPROP): biosynthesis of Und-PP-GlcNAc
source of UDP-ManNAcAManNAcAYESGenProp0969 (GENPROP): biosynthesis of UDP-N-acetyl-D-mannosaminuronic acid (UDP-ManNAcA)
lipid III synthase (Fuc4NAc transferase), WecFWecFYESPF07429 (HMM): 4-alpha-L-fucosyltransferase glycosyl transferase group 56
UDP-N-acetyl-D-mannosaminuronic acid transferase, WecGWecGYESTIGR00696 (HMM-CLUST): glycosyltransferase, WecB/TagA/CpsF family
ECA transporter (flippase), wzxwzxEYES2771 (RULE_BASE)
ECA-specific polymerase, wzywzyEYESPF06899 (HMM): ECA biosynthesis protein WzyE
ECA-specific chain length determinant protein, wzzwzzEYESPF02706 (HMM-CLUST): chain length determinant protein