Genome Property Definition Page
| Accession | GenProp0966 |
| Name | E. coli O-antigen biosynthesis |
| Type | METAPATH |
| Description | In E. coli biosynthesis of the O-antigen consists of initiation by ligation of (usually) N-acetyl-glucosamine to undecaprenylphosphate (Und-P) to form Und-PP-GlcNAc, followed by O-antigen specific ligation of several nucleotide triphosphate sugars onto the initiating GlcNAc residue. The completed Und-PP-O-antigen monomer is transferred to the periplasmic face of the membrane, polymerized and ligated to the lipid A outer core by one of three systems: The Wzy-dependent path consisting of Wzx, Wzy, and Wzz; the ABC-transporter-dependent pathway and the synthase-dependent pathway. The Wzy-pathway is most common in E. coli. |
| Parent Property | GenProp0297: lipopolysaccharide biosynthesis |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| O-antigen export system | Export | YES | GenProp0968 (GENPROP): O-antigen polymerization/export system wzx/wzy/wzz | |
| Initiation: Und-PP-GlcNAc formation | Init | YES | GenProp0970 (GENPROP): biosynthesis of Und-PP-GlcNAc | |
| ligation to Lipid A core | Ligate | YES | PF04932 (HMM): O-antigen ligase | |
| O-antigen monomer biosynthesis | O-ag | YES | GenProp0913 (GENPROP): E. coli O-antigen monomer biosynthesis clusters |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0297 | lipopolysaccharide biosynthesis |
Child Properties
| Accession | Name |
|---|---|
| GenProp0913 | E. coli O-antigen monomer biosynthesis clusters |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0203 | LPS inner core biosynthesis, ketodeoxyoctonate and heptose type |
| GenProp0204 | KDO(2)-lipid A (Re LPS) biosynthesis and delivery |
| GenProp0925 | Leptospira core LPS elements |
| GenProp0929 | LPS outer core, E. coli type |
| GenProp0994 | Leptospira interrogans-specific LPS components |
| GenProp0995 | Leptospira interrogans LPS associated transketolase |