Genome Property Definition Page
| Accession | GenProp0961 |
| Name | heme metabolism pair HutWX |
| Type | SYSTEM |
| Description | The hutW and hutX genes are found in Vibrio cholerae next to hutZ, which is essential for heme utilization. HutW is homologous to the heme carrier protein HemS, while HutW is homologous to (but does not complement) the heme biosynthesis protein HemN. The gene pair is occasionally fused, and may perform a salvage-like function, converting one form of heme into another. HutZ, which resembles the PPOX class heme oxidase HugZ, accompanies roughly half of the occurrences of HutW and HutX. |
| Parent Property | GenProp0820: iron metabolism |
| Gene Ontology Term | GO:0042168: heme metabolic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| heme utilization radical SAM enzyme HutW | HutW | YES | TIGR04107 (HMM): putative heme utilization radical SAM enzyme HutW | GO:0042168: heme metabolic process |
| putative heme utilization carrier protein HutX | HutX | YES | TIGR04108 (HMM): putative heme utilization carrier protein HutX | GO:0042168: heme metabolic process |
| heme utilization protein HutZ | HutZ | NO | TIGR04110 (HMM): heme utilization protein HutZ | GO:0042168: heme metabolic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0820 | iron metabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0627 | gene pair involved in iron and oxygen metabolism |
| GenProp0770 | siderophore biosynthesis |
| GenProp0774 | ferric citrate transport system |
| GenProp0828 | heme uptake system, NEAT-domain mediated |