| Accession | GenProp0948 |
| Name | RNA repair, Hen1/Pnkp system |
| Type | SYSTEM |
| Description | This property describe the combination of an RNA modification enzyme, the methyltransferase Hen1, and an RNA repair enzyme, polynucleotide kinase-phosphatase, as found in model species Clostridium thermocellum and in many other bacteria in a two-gene cassette. This pairing may allow RNA cleaved by ribotoxins to be repaired, and to be modified at the site of repair to prevent the same breakage from occurring again. |
| JCVI Role | RNA processing |
| Parent Property | GenProp0819: RNA metabolism
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| Literature References | [ 1 ]Keppetipola N, Shuman S Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase. Nucleic Acids Res. 2007;35(22):7721-32. Epub 2007 Nov 5. PMID 17986465
[ 2 ]Jain R, Shuman S Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. RNA. 2010 Feb;16(2):316-23. Epub 2009 Dec 9. PMID 20007328
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| Gene Ontology Term | GO:0042245: RNA repair (biological_process)
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