Genome Property Definition Page

Accession

GenProp0927

Name

bacillithiol biosynthesis

Type

PATHWAY

Description

This property describes the biosynthesis of bacillithiol, a thiol analog of glutathione and mycothiol. Bacillithiol is a 398-Da alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid

JCVI Role

Glutathione and analogs

Parent Property

GenProp0184: cofactor biosynthesis

Literature References

[ 1 ]Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. Epub 2010 Mar 22. PMID 20308541
[ 2 ]Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A Characterization of the N-Acetyl-alpha-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis . Biochemistry. 2010 Sep 28;49(38):8398-414. PMID 20799687

Gene Ontology Term

GO:0071793: bacillithiol biosynthetic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
glycosyltransferase BshA	BshA	YES	TIGR03999 (HMM): N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	GO:0071793: bacillithiol biosynthetic process
N-acetylhydrolase BshB	BshB	YES	TIGR04000 (HMM): bacillithiol biosynthesis deacetylase BshB2 TIGR04001 (HMM): bacillithiol biosynthesis deacetylase BshB1	GO:0071793: bacillithiol biosynthetic process GO:0071793: bacillithiol biosynthetic process
cysteine-adding enzyme BshC	BshC	YES	TIGR03998 (HMM): bacillithiol biosynthesis cysteine-adding enzyme BshC	GO:0071793: bacillithiol biosynthetic process

Parent Properties

Accession	Name
GenProp0184	cofactor biosynthesis

Sibling Properties

Accession	Name
GenProp0001	chorismate biosynthesis via shikimate
GenProp0030	glutathione biosynthesis
GenProp0036	biotin biosynthesis
GenProp0038	tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057	NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112	riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124	pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136	ubiquinone biosynthesis from chorismate, aerobic
GenProp0140	iron-sulfur cluster assembly systems
GenProp0170	coenzyme PQQ biosynthesis
GenProp0171	coenzyme A biosynthesis from pantothenate
GenProp0194	siroheme biosynthesis from uroporphrinogen-III
GenProp0220	uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221	protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222	protoheme from protoporphyrin IX
GenProp0250	thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp0255	5-aminolevulinate biosynthesis
GenProp0261	thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274	coenzyme B12 biosynthesis - overview
GenProp0300	photosynthetic cofactor biosynthesis
GenProp0466	molybdopterin biosynthesis
GenProp0752	ergothioneine biosynthesis
GenProp0753	mycothiol biosynthesis
GenProp0759	para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791	coenzyme F420 biosynthesis
GenProp0792	7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836	menaquinone biosynthesis
GenProp0860	tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862	pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863	pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891	coenzyme M biosynthesis
GenProp0917	mycofactocin system
GenProp1064	ovothiol biosynthesis
GenProp1096	coenzyme B biosynthesis