| Accession | GenProp0876 |
| Name | decarboxylation/antiport proton-motive cycle: glutamate-GABA |
| Type | SYSTEM |
| Description | The decarboxylation of glutamate to 4-aminobutanoate, also known as gamma-aminobutyrate or GABA, coupled with glutamate-GABA antiport, provides a robust mechanism of glutamate-based acid resistance for Escherichia coli and other organisms that need to survive transient exposures to highly acidic pH. Import of the negatively charged glutamate, decarboxylation with the consumption of a proton, and export of the neutral molecule GABA serves to reduce cytosolic acidity. Similar cycles are driven by the decarboxylation of other amino acids. |
| JCVI Role | Adaptations to atypical conditions |
| Parent Property | GenProp0873: ion-motive antiporter cycles
|
| Literature References | [ 1 ] Kailasan Vanaja S, Bergholz TM, Whittam TS Characterization of the Escherichia coli O157:H7 Sakai GadE regulon. J Bacteriol. 2009 Mar;191(6):1868-77. PMID 19114477
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| Gene Ontology Term | GO:0010447: response to acidity (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| glutamate decarboxylase | gadAB | YES | TIGR01788 (HMM): glutamate decarboxylase | GO:0010447: response to acidity
|
| glutamate/GABA antiporter | gadC | YES | TIGR00910 (HMM): glutamate:gamma-aminobutyrate antiporter | GO:0010447: response to acidity
|
| transcriptional activator GadE | gadE | NO | 2656 (RULE_BASE)
| GO:0010447: response to acidity
|
| transcriptional activator GadW | gadW | NO | 2655 (RULE_BASE)
| GO:0010447: response to acidity
|
| transcriptional regulator GadX | gadX | NO | 2657 (RULE_BASE)
| GO:0010447: response to acidity
|
