Genome Property Definition Page
| Accession | GenProp0813 | |
| Name | pyrimidine utilization operon, RutABCDEFGR | |
| Type | PATHWAY | |
| Description | This seven-gene operon described in E. coli K-12 [1] is responsible for the degradation of uracil, and to a lesser extent, thymine. This has been determined by growth and mutation experiments. The operon contains a luciferase family member (RutA) which likely catalyzes the FMN-dependent critical oxidation for the ring opening as well as RutF which may be involved in recycling the FMN cofactor. Other seemingly essential components are an isochorismate mutase family protein (RutB), a hydrolase (RutD) and a member of the L-PSP endoribonuclease family (RutC) and a regulatory protein (RutR). The transporter RutG found in E. coli is not found in all genomes harboring the rest of the operon and may be replaced by other non-homologous transporters located elsewhere in the genomes. This property appears to be limited to the alpha and gamma proteobacteria. | |
| Parent Property | GenProp0142: catabolism GenProp0817: nucleotide catabolism/utilization pathways | |
| Literature References |
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Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| FMN-dependent luciferase family monoxygenase RutA | RutA | YES | TIGR03612 (HMM): pyrimidine utilization protein A | |
| isochorismate mutase family protein RutB | RutB | YES | TIGR03614 (HMM): pyrimidine utilization protein B | |
| L-PSP endoribonuclease family protein RutC | RutC | YES | TIGR03610 (HMM): pyrimidine utilization protein C | |
| hydrolase protein RutD | RutD | YES | TIGR03611 (HMM): pyrimidine utilization protein D | |
| nitroreductase family protein RutE | RutE | NO | PF00881 (HMM-CLUST): nitroreductase family protein | |
| flavin reductase RutF | RutF | YES | TIGR03615 (HMM): pyrimidine utilization flavin reductase protein F | |
| uracil-xanthine permease family protein RutG | RutG | NO | TIGR03616 (HMM): pyrimidine utilization transport protein G | |
| clustered regulatory protein | RutR | NO | TIGR03613 (HMM): pyrimidine utilization regulatory protein R |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0142 | catabolism |
| GenProp0817 | nucleotide catabolism/utilization pathways |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0055 | polyhydroxyalkanoic acids |
| GenProp0141 | galactose-6-phosphate degradation via tagatose-6-phosphate |
| GenProp0156 | cyanophycin-like storage polymers |
| GenProp0168 | glycogen system |
| GenProp0210 | phenylacetic acid catabolism |
| GenProp0231 | 4-hydroxyphenylacetate degradation |
| GenProp0233 | GABA utilization |
| GenProp0238 | 2-aminoethylphosphonate catabolism to acetaldehyde |
| GenProp0239 | propionyl-CoA catabolism |
| GenProp0241 | phosphonate catabolism |
| GenProp0271 | trehalose utilization |
| GenProp0272 | pyruvate fermentation to acetoin |
| GenProp0273 | protocatechuate degradation to beta-ketoadipate |
| GenProp0283 | beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA |
| GenProp0294 | ethanolamine degradation proteinaceous organelle |
| GenProp0457 | rhamnose catabolism |
| GenProp0458 | fucose catabolism |
| GenProp0461 | utilization of deoxynucleosides |
| GenProp0653 | ectoine catabolism |
| GenProp0674 | malonate decarboxylase |
| GenProp0686 | allantoin catabolism to glyoxalate and urea |
| GenProp0687 | allantoin catabolism to oxamate and carbamoyl-phosphate |
| GenProp0688 | urate catabolism to allantoin |
| GenProp0691 | glycolysis |
| GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
| GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
| GenProp0700 | purine catabolism via urate, xanthine and allantoin |
| GenProp0702 | benzoyl-CoA reductase |
| GenProp0703 | 4-hydroxybenzoyl-CoA reductase |
| GenProp0706 | cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway |
| GenProp0708 | catechol meta-cleavage pathway |
| GenProp0709 | benzoate catabolism BoxABC pathway |
| GenProp0711 | catechol ortho-cleavage upper pathway |
| GenProp0714 | galactarate utilization via tartronate semi-aldehyde |
| GenProp0715 | galactarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0716 | glucarate utilization via tartronate semi-aldehyde |
| GenProp0717 | glucarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0718 | oxalate degradation |
| GenProp0734 | amino acid catabolism |
| GenProp0749 | choline sulfate utilization |
| GenProp0760 | putrescine degradation to GABA via gamma-glutamylation |
| GenProp0763 | nicotinate fermentation to pyruvate and propionate |
| GenProp0810 | encapsulin proteinaceous organelle |
| GenProp0902 | quinohemoprotein amine dehydrogenase |
| GenProp1071 | myo-inositol catabolism |
| GenProp1072 | cyanase system |
| GenProp1076 | choline TMA-lyase system |
| GenProp0640 | xanthine dehydrogenase |
| GenProp0696 | xanthine utilization as a source of guanine-monophosphate (GMP) |
| GenProp0705 | xanthine dehydrogenase, bacillus type (pucABCDE) |