Genome Property Definition Page
| Accession | GenProp0761 | |
| Name | hopanoid lipid biosynthesis | |
| Type | PATHWAY | |
| Description | Hopanoids are pentacyclic steroid-like compounds derived from squalene (a diterpene) by cyclization and various elaborations of the side chain. Methylations of the polycyclic body of the molecule have also been reported. The essential enzymes are squalene synthase which condenses two molecules of farnesyl-pyrophosphate and squalene-hopene cyclase. | |
| Parent Property | GenProp0838: lipid biosynthesis | |
| Literature References |
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| Gene Ontology Term | GO:0019746: hopanoid biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| nucleotide-sugar epimerase/dehydratase | HpnA | NO | TIGR03466 (HMM): hopanoid-associated sugar epimerase | GO:0019746: hopanoid biosynthetic process |
| glycosyl transferase, family 2, HpnB | HpnB | NO | TIGR03469 (HMM): hopene-associated glycosyltransferase HpnB | GO:0019746: hopanoid biosynthetic process |
| squalene synthase, HpnC and/or HpnD subunits | HpnCD | YES | TIGR03464 (HMM): squalene synthase HpnC TIGR03465 (HMM): squalene synthase HpnD | GO:0019746: hopanoid biosynthetic process GO:0019746: hopanoid biosynthetic process |
| FAD-dependent desaturase, HpnE | HpnE | NO | TIGR03467 (HMM): squalene-associated FAD-dependent desaturase | GO:0019746: hopanoid biosynthetic process |
| phosphorylase, HpnG | HpnG | NO | TIGR03468 (HMM): hopanoid-associated phosphorylase | GO:0019746: hopanoid biosynthetic process |
| radical SAM enzyme, HpnH | HpnH | YES | TIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH | GO:0019746: hopanoid biosynthetic process |
| glycosyl transferase, family 2, HpnI | HpnI | NO | TIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI | GO:0019746: hopanoid biosynthetic process |
| radical SAM enzyme, HpnJ | HpnJ | NO | TIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ | GO:0019746: hopanoid biosynthetic process |
| YdjC-like enzyme, HpnK | HpnK | NO | TIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK | GO:0019746: hopanoid biosynthetic process |
| putative membrane protein, TIGR00374 superfamily, HpnL | HpnL | NO | TIGR03476 (HMM): putative membrane protein | GO:0019746: hopanoid biosynthetic process |
| toluene tolerance protein homolog, HpnM | HpnM | NO | TIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM | GO:0019746: hopanoid biosynthetic process |
| RND efflux transporter homolog, HpnN | HpnN | NO | TIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN | |
| VacJ like lipoprotein | HpnO | NO | PF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA | GO:0019746: hopanoid biosynthetic process |
| hopanoid C-3 methylase | HpnR | NO | TIGR04367 (HMM): hopanoid C-3 methylase HpnR | GO:0019746: hopanoid biosynthetic process |
| squalene-hopene cyclase | SHC | YES | TIGR01507 (HMM): squalene-hopene cyclase | GO:0019746: hopanoid biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0838 | lipid biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0046 | IPP biosynthesis |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0299 | fatty acid biosynthesis |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0837 | 1-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway |