Accession | GenProp0744 |
Name | glyoxalase pathway, glutathione dependent |
Type | PATHWAY |
Description | Glyoxalase I and glyoxalase II are the enzymes lactoylglutathione lyase (EC 4.4.1.5) and hydroxyacylglutathione hydrolase (EC 3.1.2.6), respectively. This system detoxifies methylglyoxal and other highly reactive aldehydes. Glutathione serves a cofactor; variants of this pathway may occur where glutathione is replaced by another cofactor such as trypanothione in Trypanosoma cruzi (see PMID:16958620).
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JCVI Role | Detoxification |
Parent Property | GenProp0303: detoxification
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Literature References | [ 1 ]O'Young J, Sukdeo N, Honek JF Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. Epub 2006 Dec 6. PMID 17196158 |
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Gene Ontology Term | GO:0051596: methylglyoxal catabolic process (biological_process)
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