| Accession | GenProp0739 |
| Name | iron-sulfur cluster assembly CsdA-CsdE system |
| Type | SYSTEM |
| Description | The heteromeric complex of CsdA and CsdE plays a role in iron-sulfur (Fe-S) cluster biosynthesis, as do the better-known systems ISC, SUF, and NIF. CdsA, a homolog of SufS, IscS, and NifS, is a cysteine desulfurase catalytic subunit. CdsE, a SufE homolog, physically interacts and accepts a sulfur at Cys-61 (numbered as in Escherichia coli). In contrast to sulfur-accepting components such as NifU and IscU, CsdE does not bind iron and is not viewed as a scaffold on which Fe-S cluster biosynthesis can be completed prior to transfer to other proteins. Rather, this simplicity of this system may reflect a limited role for the maturation of specific Fe-S cluster-containing proteins. |
| JCVI Role | Other |
| Parent Property | GenProp0140: iron-sulfur cluster assembly systems
|
| Literature References | [ 1 ]Loiseau L, Ollagnier-de Choudens S, Lascoux D, Forest E, Fontecave M, Barras F Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli. J Biol Chem. 2005 Jul 22;280(29):26760-9. PMID 15901727
|
|
| Gene Ontology Term | GO:0016226: iron-sulfur cluster assembly (biological_process)
|
