| Accession | GenProp0726 |
| Name | selenium-dependent molybdenum hydroxylase system |
| Type | SYSTEM |
| Description | The enzyme selenide,water dikinase (SelD) activates selenium for use in bacteria as selenocysteine to be incorporated during protein translation or as the modified base selenouridine in certain tRNAs. However, SelD occurs in some genomes with neither of those traits, and instead acts in the post-translational addition of a labile selenium to a molybdenum-containing cofactor. A bioinformatic analysis showed that the family of TIGRFAMs model TIGR03309 represents a third selenium-dependent bacterial trait, and that it is quite widespread. The current version of this Genome Property includes both selenium cofactor maturation proteins and subunits of predicted labile selenium cofactor enzymes. |
| Parent Property | GenProp0075: protein modification, prosthetic groups and cofactors
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| Literature References | [ 1 ]Self WT, Stadtman TC Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7208-13. PMID 10860985
[ 2 ]Self WT, Wolfe MD, Stadtman TC Cofactor determination and spectroscopic characterization of the selenium-dependent purine hydroxylase from Clostridium purinolyticum. Biochemistry. 2003 Sep 30;42(38):11382-90. PMID 14503889
[ 3 ]Dobbek H, Gremer L, Meyer O, Huber R Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8884-9. PMID 10430865
[ 4 ]Srivastava M, Mallard C, Barke T, Hancock LE, Self WT A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production. J Bacteriol. 2011 Apr;193(7):1643-52. PMID 21257770
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| diaminopropionate ammonia-lyase | 23_DAP | NO | TIGR03528 (HMM): diaminopropionate ammonia-lyase | |
| selenium-dependent molybdenum hydroxylase, protein 1 | Se_AA | YES | TIGR03309 (HMM): selenium-dependent molybdenum hydroxylase system protein, YqeB family | |
| selenium-dependent molybdenum hydroxylase, protein 3 | Se_CC | YES | TIGR03172 (HMM): putative selenium-dependent hydroxylase accessory protein YqeC | |
| molybdenum cofactor cytidylyltransferase | Se_MocA | YES | TIGR03310 (HMM): molybdenum cofactor cytidylyltransferase | |
| selenide, water dikinase | Se_SelD | NO | TIGR00476 (HMM): selenide, water dikinase | |
| selenium metabolism protein YedF | Se_YedF | NO | TIGR03527 (HMM): selenium metabolism protein YedF | |
| selenium-dependent xanthine dehydrogenase | Se_enz1 | NO | TIGR03311 (HMM): selenium-dependent xanthine dehydrogenase | |
| probable selenate reductase, FAD-binding subunit | Se_enz2 | NO | TIGR03312 (HMM): probable selenate reductase, FAD-binding subunit | |
| probable selenate reductase, molybdenum subunit | Se_enz3 | NO | TIGR03313 (HMM): probable selenate reductase, molybdenum-binding subunit | |
| probable selenate reductase, YgfK subunit | Se_enz4 | NO | TIGR03315 (HMM): putative selenate reductase, YgfK subunit | |
| putative selenium metabolism hydrolase | Se_prot | NO | TIGR03526 (HMM): putative selenium metabolism hydrolase | |
