| Accession | GenProp0629 |
| Name | A1/A0 ATPase |
| Type | SYSTEM |
| Description | This ATP synthase is the archaebacterial version of the F1/F0 ATP synthase found in bacteria in the sense that it functions in the ATP synthetic direction [1], although it also has similarities to the V1/V0 (V-type, vacuolar) ATPase in eucarya which hydrolyzes ATP in order to acidify cellular compartments. |
| JCVI Role | ATP-proton motive force interconversion |
| Parent Property | GenProp0243: ATP synthases
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| Literature References | [ 1 ]Wilms R, Freiberg C, Wegerle E, Meier I, Mayer F, Muller V Subunit structure and organization of the genes of the A1A0 ATPase from the Archaeon Methanosarcina mazei Go1. J Biol Chem. 1996 Aug 2;271(31):18843-52. PMID 8702544
[ 2 ]Lemker T, Gruber G, Schmid R, Muller V Defined subcomplexes of the A1 ATPase from the archaeon Methanosarcina mazei Go1: biochemical properties and redox regulation. FEBS Lett. 2003 Jun 5;544(1-3):206-9. PMID 12782317
[ 3 ]Coskun U, Radermacher M, Muller V, Ruiz T, Gruber G Three-dimensional organization of the archaeal A1-ATPase from Methanosarcina mazei Go1. J Biol Chem. 2004 May 21;279(21):22759-64. Epub 2004 Feb 26. PMID 14988401
[ 4 ]Muller V, Ruppert C, Lemker T Structure and function of the A1A0-ATPases from methanogenic Archaea. J Bioenerg Biomembr. 1999 Feb;31(1):15-27. PMID 10340845
[ 5 ]Ruppert C, Wimmers S, Lemker T, Muller V The A1A0 ATPase from Methanosarcina mazei: cloning of the 5' end of the aha operon encoding the membrane domain and expression of the proteolipid in a membrane-bound form in Escherichia coli. J Bacteriol. 1998 Jul;180(13):3448-52. PMID 9642200
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| A1 stalk complex, A subunit | AhaA | YES | TIGR01043 (HMM): ATP synthase archaeal, A subunit | |
| A1 stalk complex, B subunit | AhaB | YES | TIGR01041 (HMM): ATP synthase archaeal, B subunit | |
| A1 stalk complex, C subunit | AhaC | YES | TIGR02923 (HMM): ATP synthase A1, C subunit | |
| A1 stalk complex, D subunit | AhaD | YES | TIGR00309 (HMM): V-type ATPase, D subunit | |
| A1 stalk complex, E subunit | AhaE | YES | PF01991 (HMM): ATP synthase (E/31 kDa) subunit | |
| A1 stalk complex, F subunit | AhaF | YES | PF01990 (HMM): ATP synthase (F/14-kDa) subunit | |
| A1 stalk complex, G subunit | AhaG | NO | | |
| H subunit | AhaH | NO | TIGR02926 (HMM): ATP synthase archaeal, H subunit | |
| A0 membrane complex, I subunit | AhaI | NO | | |
| A0 membrane complex, K subunit | AhaK | NO | | |
