Genome Property Definition Page
| Accession | GenProp0611 |
| Name | aerobic respiration |
| Type | METAPATH |
| Description | Aerobic respiration is the complex series of pathways in which a common organic intermediate (generally pyruvate) is broken down into carbon dioxide (CO2) and water (H20) with the concomitant production of ATP in the presence of oxygen. Pyruvate is generated from glucose via glycolysis. The first step of this process is conversion of pyruvate to acetyl-CoA which then enters the Krebs (or, TCA) cycle. Acetyl-CoA may also be generated independently of pyruvate via the breakdown of other organic compounds. The TCA cycle generates reducing equivalents in the form of NADH. NADH, in turn delivers the electrons to the top of the electron transport chain (oxidative phosphorylation). This chain results in the pumping of protons (and/or sodium ions) to form a gradient. Ions flowing back with this gradient power the ATP-generation machines of the cell. Oxygen acts as the terminal electron acceptor for the electron-transport chain. |
| Parent Property | GenProp0070: energy metabolism |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| Generation of a ATP from ADP utilizing a proton (or sodium ion) gradient | ATPsynth | YES | GenProp0128 (GENPROP): F1/F0 ATPase GenProp0629 (GENPROP): A1/A0 ATPase | |
| Generation of a proton (or sodium ion) gradient by the coupling of NADH oxidation (to NAD+) with oxygen reduction (to water) | ETC | YES | GenProp0612 (GENPROP): aerobic electron transfer (transport) chain, ETC | |
| Generation of NADH from NAD+ by oxidation of electron donor molecules | TCAcyc | YES | GenProp0033 (GENPROP): TCA cycle |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0070 | energy metabolism |
Child Properties
| Accession | Name |
|---|---|
| GenProp0033 | TCA cycle |
| GenProp0128 | F1/F0 ATPase |
| GenProp0612 | aerobic electron transfer (transport) chain, ETC |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0011 | methanogenesis |
| GenProp0023 | glyoxylate shunt |
| GenProp0027 | photosynthesis |
| GenProp0033 | TCA cycle |
| GenProp0120 | pentose phosphate cycle |
| GenProp0131 | electron transport |
| GenProp0243 | ATP synthases |
| GenProp0298 | fermentation |
| GenProp0459 | D-xylose utilization (conversion to D-xylulose-5-phosphate) |
| GenProp0468 | Entner-Doudoroff pathway |
| GenProp0473 | arsenite oxidase |
| GenProp0636 | respiratory nitrate reductase |
| GenProp0637 | anaerobic dimethyl sulfoxide reductase |
| GenProp0638 | trimethylamine N-oxide reductase system |
| GenProp0682 | formate-dependent nitrite reductase, seven-gene type |
| GenProp0683 | cytochrome c nitrite reductase NrfHA |
| GenProp0691 | glycolysis |
| GenProp0695 | cytochrome b558/566 |
| GenProp0723 | hydrogenase, nickel and F420-dependent |
| GenProp0737 | anaerobic glycerol-3-phosphate dehydrogenase complex |
| GenProp0755 | pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating |
| GenProp0756 | fumarate reductase complex |
| GenProp0764 | DMSO reductase family type II enzyme |
| GenProp0841 | 2-oxoacid:ferredoxin oxidoreductase |
| GenProp0856 | bacterio-opsin system |
| GenProp0914 | hydrogenase, [FeFe]-dependent |
| GenProp0915 | hydrogenase, mono-iron type |
| GenProp1089 | B12-dependent trimeric diol/glycerol dehydratase |
| GenProp1101 | quinoprotein cytochrome relay system |