Genome Property Definition Page
Accession | GenProp0291 | |
Name | class III (anaerobic) ribonucleotide reductase | |
Type | SYSTEM | |
Description | Ribonucleotide reductases (RNRs) are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. The class III RNRs consist of two components, the catalytic enzyme (NrdD) and a radical-SAM domain enzyme (NrdG) which activates the catalytic enzyme by the generation of a protein-centered radical. | |
JCVI Role | 2'-Deoxyribonucleotide metabolism | |
Parent Property | GenProp0287: ribonucleotide reduction | |
Literature References |
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Gene Ontology Term | GO:0009265: 2'-deoxyribonucleotide biosynthetic process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
anaerobic ribonucleoside-triphosphate reductase | NrdD | YES | TIGR02487 (HMM): anaerobic ribonucleoside-triphosphate reductase TIGR02827 (HMM): anaerobic ribonucleoside-triphosphate reductase | GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process |
activating protein for anaerobic ribonucleotide triphosphate reductase | NrdG | YES | TIGR02491 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein TIGR02495 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein TIGR02826 (HMM): anaerobic ribonucleoside-triphosphate reductase activating protein | GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process GO:0009265: 2'-deoxyribonucleotide biosynthetic process |
Parent Properties
Accession | Name |
---|---|
GenProp0287 | ribonucleotide reduction |
Sibling Properties
Accession | Name |
---|---|
GenProp0289 | class I (aerobic) ribonucleotide reductase |
GenProp0290 | class II (B12-dependent) ribonucleotide reductase |