Genome Property Definition Page

Accession

GenProp0262

Name

RNA polymerase, bacterial

Type

SYSTEM

Description

This property describes the bacterial multisubunit DNA-directed RNA polymerase (EC 2.7.7.6). This property does not include sigma factors (at present), which are regulatory and varied, and so by definition describes the core enzyme rather than the holoenzyme. Subunit stochiometry is two alpha subunits to one each of beta and beta'. In Cyanobacteria and plastids, beta' is replaced by two proteins, one like the N-term of beta' (called gamma in Cyanobacteria and, confusingly, beta' in plastids) and one like the C-term of beta' (called beta' in Cyanobacteria and beta'' in plastids).

JCVI Role

DNA-dependent RNA polymerase

Parent Property

GenProp0819: RNA metabolism

Literature References

[ 1 ]Seo PS, Yokota A The phylogenetic relationships of cyanobacteria inferred from 16S rRNA, gyrB, rpoC1 and rpoD1 gene sequences. J Gen Appl Microbiol 2003 Jun;49(3):191-203. PMID 12949700
[ 2 ]Kojima I, Kasuga K, Kobayashi M, Fukasawa A, Mizuno S, Arisawa A, Akagawa H The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis. J Bacteriol 2002 Dec;184(23):6417-23. PMID 12426327

Web References

KEGG: RNA polymerase

Components

Step Name	Step Num	Required	Evidence (Method)
APPARENT DISRUPTED READING FRAMES	DISRPT	NO	FRAMESHIFT (MANUAL)
RNA polymerase delta	rnaPdlt	NO	TIGR04567 (HMM): DNA-directed RNA polymerase delta subunit
RNA polymerase alpha	rpoA	YES	TIGR02027 (HMM): DNA-directed RNA polymerase, alpha subunit
RNA polymerase beta	rpoB	YES	TIGR02013 (HMM): DNA-directed RNA polymerase, beta subunit
RNA polymerase beta', C-terminal region	rpoC_C	YES	TIGR02388 (HMM): DNA-directed RNA polymerase, beta'' subunit TIGR02386 (HMM): DNA-directed RNA polymerase, beta' subunit
RNA polymerase beta', C-terminal	rpoC_N	YES	TIGR02387 (HMM): DNA-directed RNA polymerase, gamma subunit TIGR02386 (HMM): DNA-directed RNA polymerase, beta' subunit
RNA polymerase omega	rpoZ	NO	TIGR00690 (HMM): DNA-directed RNA polymerase, omega subunit

Parent Properties

Accession	Name
GenProp0819	RNA metabolism

Sibling Properties

Accession	Name
GenProp0258	tRNA aminoacylation
GenProp0482	6S RNA (eubacterial RNA polymerase regulator)
GenProp0677	queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0692	selenouridine-containing tRNA
GenProp0704	tRNA U34 carboxymethylaminomethyl modification
GenProp0898	RNA ligase/unknown protein pair
GenProp0948	RNA repair, Hen1/Pnkp system
GenProp1060	tRNA N6-threonylcarbamoyladenosine modification
GenProp1077	tRNA(Pro) cmo5UGG modification
GenProp1082	16S rRNA C1402 m(4)Cm modification