Genome Property Definition Page
Accession | GenProp0231 | |
Name | 4-hydroxyphenylacetate degradation | |
Type | PATHWAY | |
Description | 4-hydroxyphenylacetic acid, a degradation product of tyrosine via one of several routes, of phenylalanine via phenylacetate, and of environmental DDT is metabolized in this pathway to the common metabolites succinate and pyruvate via homoprotocatechuate. 4-hydroxyphenylacetic acid may also be found in the environment and transported into the cell. The genes encoding the components of this pathway are often organized into apparent operons which include regulatory elements as well as a variety of transport systems. A number of genomes show partial evidence of the pathway based on homologs of the well-characterized enzymes from other species. Often, promising candidates for the missing steps are found in the vicinity. These are suggestive of enzymes which have been adapted from ancestral sequences having a different function. Of course, the possibility exists that it is the entire pathway that has been modified in these species and it is other structurally related compounds that are being metabolized instead of 4-hydroxyphenylacetic acid. | |
Parent Property | GenProp0142: catabolism | |
Literature References |
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Web References | Tyrosine metabolism - reference pathway | |
Gene Ontology Term | GO:0009894: regulation of catabolic process (biological_process) GO:0042537: benzene-containing compound metabolic process (biological_process) GO:0046942: carboxylic acid transport (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
APPARENT DISRUPTED READING FRAMES | DISRPT | NO | FRAMESHIFT (MANUAL) | |
succinate-semialdehyde dehydrogenase | SSDH | YES | TIGR01780 (HMM): succinate-semialdehyde dehydrogenase | |
regulatory protein, HpaA | hpaA | NO | TIGR02297 (HMM): 4-hydroxyphenylacetate catabolism regulatory protein HpaA | GO:0009894: regulation of catabolic process |
4-hydroxyphenylacetate 3-monooxygenase, large subunit | hpaB | YES | TIGR02309 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component TIGR02310 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component | GO:0042537: benzene-containing compound metabolic process GO:0042537: benzene-containing compound metabolic process |
4-hydroxyphenylacetate 3-monooxygenase, small subunit | hpaC | YES | TIGR02296 (HMM): 4-hydroxyphenylacetate 3-monooxygenase, reductase component | GO:0042537: benzene-containing compound metabolic process |
3,4-dihydroxyphenylacetate 2,3-dioxygenase (1.13.11.15) | hpaD | YES | TIGR02295 (HMM): 3,4-dihydroxyphenylacetate 2,3-dioxygenase TIGR02298 (HMM): 3,4-dihydroxyphenylacetate 2,3-dioxygenase | GO:0042537: benzene-containing compound metabolic process GO:0042537: benzene-containing compound metabolic process |
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (1.2.1.60) | hpaE | YES | TIGR02299 (HMM): 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | GO:0042537: benzene-containing compound metabolic process |
5-carboxymethyl-2-hydroxymuconate delta-isomerase (5.3.3.10) | hpaF | YES | PF02962 (HMM): 5-carboxymethyl-2-hydroxymuconate delta isomerase | GO:0042537: benzene-containing compound metabolic process |
bifunctional decarboxylase/isomerase, C-terminal | hpaG-C | YES | TIGR02303 (HMM): 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit | GO:0042537: benzene-containing compound metabolic process |
bifunctional decarboxylase/isomerase, N-terminal | hpaG-N | YES | TIGR02305 (HMM): 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit | GO:0042537: benzene-containing compound metabolic process |
2-oxo-hepta-3-ene-1,7-dioate hydratase | hpaH | YES | TIGR02312 (HMM): 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | GO:0042537: benzene-containing compound metabolic process |
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase | hpaI | YES | TIGR02311 (HMM): 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase TIGR02313 (HMM): 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase | GO:0042537: benzene-containing compound metabolic process GO:0042537: benzene-containing compound metabolic process |
regulatory protein, HpaR | hpaR | NO | TIGR02337 (HMM): homoprotocatechuate degradation operon regulator, HpaR | GO:0009894: regulation of catabolic process |
probable 4-hydroxyphenylacetate transporters | trnsprt | NO | TIGR02332 (HMM): 4-hydroxyphenylacetate permease | GO:0046942: carboxylic acid transport |
Parent Properties
Accession | Name |
---|---|
GenProp0142 | catabolism |
Sibling Properties
Accession | Name |
---|---|
GenProp0055 | polyhydroxyalkanoic acids |
GenProp0141 | galactose-6-phosphate degradation via tagatose-6-phosphate |
GenProp0156 | cyanophycin-like storage polymers |
GenProp0168 | glycogen system |
GenProp0210 | phenylacetic acid catabolism |
GenProp0233 | GABA utilization |
GenProp0238 | 2-aminoethylphosphonate catabolism to acetaldehyde |
GenProp0239 | propionyl-CoA catabolism |
GenProp0241 | phosphonate catabolism |
GenProp0271 | trehalose utilization |
GenProp0272 | pyruvate fermentation to acetoin |
GenProp0273 | protocatechuate degradation to beta-ketoadipate |
GenProp0283 | beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA |
GenProp0294 | ethanolamine degradation proteinaceous organelle |
GenProp0457 | rhamnose catabolism |
GenProp0458 | fucose catabolism |
GenProp0461 | utilization of deoxynucleosides |
GenProp0653 | ectoine catabolism |
GenProp0674 | malonate decarboxylase |
GenProp0686 | allantoin catabolism to glyoxalate and urea |
GenProp0687 | allantoin catabolism to oxamate and carbamoyl-phosphate |
GenProp0688 | urate catabolism to allantoin |
GenProp0691 | glycolysis |
GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
GenProp0700 | purine catabolism via urate, xanthine and allantoin |
GenProp0702 | benzoyl-CoA reductase |
GenProp0703 | 4-hydroxybenzoyl-CoA reductase |
GenProp0706 | cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway |
GenProp0708 | catechol meta-cleavage pathway |
GenProp0709 | benzoate catabolism BoxABC pathway |
GenProp0711 | catechol ortho-cleavage upper pathway |
GenProp0714 | galactarate utilization via tartronate semi-aldehyde |
GenProp0715 | galactarate utilization via 2-oxoglutarate semialdehyde |
GenProp0716 | glucarate utilization via tartronate semi-aldehyde |
GenProp0717 | glucarate utilization via 2-oxoglutarate semialdehyde |
GenProp0718 | oxalate degradation |
GenProp0734 | amino acid catabolism |
GenProp0749 | choline sulfate utilization |
GenProp0760 | putrescine degradation to GABA via gamma-glutamylation |
GenProp0763 | nicotinate fermentation to pyruvate and propionate |
GenProp0810 | encapsulin proteinaceous organelle |
GenProp0813 | pyrimidine utilization operon, RutABCDEFGR |
GenProp0902 | quinohemoprotein amine dehydrogenase |
GenProp1071 | myo-inositol catabolism |
GenProp1072 | cyanase system |
GenProp1076 | choline TMA-lyase system |