Genome Property Definition Page
Accession | GenProp0217 | |
Name | 5-aminolevulinate biosynthesis (glutamate pathway) | |
Type | PATHWAY | |
Description | This pathway for the biosynthesis of 5-aminolevulinate, a porphyrin precursor, is known as the glutamate or C5 pathway and is found in most bacteria. A distinctive feature of this pathway is the utilization of an amino acid-charged tRNA as an enzymatic substrate. An alternative pathway from succinyl-CoA and glycine utilizing 5-aminolevulinate synthase is found in the alphaproteobacteria and eukaryotic mitochondria. | |
JCVI Role | Heme, porphyrin, and cobalamin | |
Parent Property | GenProp0255: 5-aminolevulinate biosynthesis | |
Literature References |
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Web References | KEGG:Porphyrin and chlorophyll metabolism | |
Gene Ontology Term | GO:0006779: porphyrin-containing compound biosynthetic process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
APPARENT DISRUPTED READING FRAMES | DISRPT | NO | AUTHENTIC POINT MUTATION (MANUAL) TRUNCATION (MANUAL) | GO:0006779: porphyrin-containing compound biosynthetic process |
glutamyl-tRNA synthetase | gltX | YES | TIGR00464 (HMM): glutamate--tRNA ligase TIGR00463 (HMM): glutamate--tRNA ligase | GO:0006779: porphyrin-containing compound biosynthetic process GO:0006779: porphyrin-containing compound biosynthetic process |
glutamyl-tRNA reductase | hemA | YES | TIGR01035 (HMM): glutamyl-tRNA reductase | GO:0006779: porphyrin-containing compound biosynthetic process |
glutamate-1-semialdehyde-2,1-aminomutase | hemL | YES | TIGR00713 (HMM): glutamate-1-semialdehyde-2,1-aminomutase | GO:0006779: porphyrin-containing compound biosynthetic process |
Parent Properties
Accession | Name |
---|---|
GenProp0255 | 5-aminolevulinate biosynthesis |
Sibling Properties
Accession | Name |
---|---|
GenProp0223 | 5-aminolevulinate biosynthesis from succinyl-CoA and glycine |