Genome Property Definition Page
| Accession | GenProp0203 |
| Name | LPS inner core biosynthesis, ketodeoxyoctonate and heptose type |
| Type | PATHWAY |
| Description | Lipopolysaccharide (LPS) occurs broadly in Gram-negative bacterial outer membrane. Three parts are termed lipid A, the oligosaccharide core, and O antigen. If lacking the repeating O-antigen, it may be termed Lipooligosaccharide (LOS). The core is often described as having inner and outer regions, and is variable among species that contain LPS/LOS. This property describes a widely distributed common chemistry for the inner core. At least two residues of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) are present, to one of which the lipid A moeity is attached. The inner core in E. coli and many other bacteria also contains at least two heptose residues, added by distinct heptosyltransferases I and II. |
| JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Parent Property | GenProp0297: lipopolysaccharide biosynthesis |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| D-sedoheptulose 7-phosphate isomerase | GmhA | YES | TIGR00441 (HMM): phosphoheptose isomerase | |
| D,D-heptose 1,7-bisphosphate phosphatase | GmhB | YES | TIGR00213 (HMM): D,D-heptose 1,7-bisphosphate phosphatase | |
| ADP-L-glycero-D-mannoheptose-6-epimerase | HldD | YES | TIGR02197 (HMM): ADP-glyceromanno-heptose 6-epimerase | |
| RfaE bifunc, domain II | HldE_C | YES | TIGR02199 (HMM): bifunctional protein RfaE, domain II | |
| RfaE bifunc, domain I | HldE_N | YES | TIGR02198 (HMM): bifunctional protein RfaE, domain I | |
| heptosyltransferase I | WaaC | YES | TIGR02193 (HMM): lipopolysaccharide heptosyltransferase I | |
| heptosyltransferase II | WaaF | YES | TIGR02195 (HMM): lipopolysaccharide heptosyltransferase II | |
| lipopolysaccharide core biosynthesis protein RfaP | WaaP | NO | PF06293 (HMM): lipopolysaccharide kinase, Kdo/WaaP family | |
| heptosyltransferase III | WaaQ | NO | TIGR02201 (HMM): putative lipopolysaccharide heptosyltransferase III | |
| lipopolysaccharide core biosynthesis protein RfaY | WaaY | NO | PF06176 (HMM): lipopolysaccharide core biosynthesis protein RfaY | |
| Kdo-III transferase | WaaZ | NO | TIGR04437 (HMM): 3-deoxy-D-manno-oct-2-ulosonate III transferase WaaZ |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0297 | lipopolysaccharide biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0204 | KDO(2)-lipid A (Re LPS) biosynthesis and delivery |
| GenProp0925 | Leptospira core LPS elements |
| GenProp0929 | LPS outer core, E. coli type |
| GenProp0966 | E. coli O-antigen biosynthesis |
| GenProp0994 | Leptospira interrogans-specific LPS components |
| GenProp0995 | Leptospira interrogans LPS associated transketolase |