Genome Property Definition Page
| Accession | GenProp0170 | |
| Name | coenzyme PQQ biosynthesis | |
| Type | SYSTEM | |
| Description | Coenzyme PQQ (coenzyme pyrrolo-quinoline-quinone) production is associated with an operon that includes a small protein, PqqA, proposed to act as a molecular precursor. PQQ is a cofactor of certain alcohol dehydrogenases and glucose dehydrogenases. | |
| JCVI Role | Other | |
| Parent Property | GenProp0184: cofactor biosynthesis | |
| Literature References |
| |
| Gene Ontology Term | GO:0018189: pyrroloquinoline quinone biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| PQQ-binding repeats | PQQ_rpt | NO | PF01011 (HMM): PQQ enzyme repeat | |
| PqqA protein | pqqA | YES | TIGR02107 (HMM): coenzyme PQQ precursor peptide PqqA | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| PqqB protein | pqqB | YES | TIGR02108 (HMM): coenzyme PQQ biosynthesis protein B | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| PqqC protein | pqqC | YES | TIGR02111 (HMM): coenzyme PQQ biosynthesis protein C | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| PqqD protein | pqqD | YES | TIGR03859 (HMM): coenzyme PQQ biosynthesis protein PqqD | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| PqqE protein | pqqE | YES | TIGR02109 (HMM): coenzyme PQQ biosynthesis enzyme PqqE | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| peptidase PqqF | pqqF | NO | TIGR02110 (HMM): coenzyme PQQ biosynthesis protein PqqF | GO:0018189: pyrroloquinoline quinone biosynthetic process |
| PQQ-dependent enzyme example | usePQQ | YES | TIGR03074 (HMM): membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family TIGR03075 (HMM): PQQ-dependent dehydrogenase, methanol/ethanol family | GO:0018189: pyrroloquinoline quinone biosynthetic process GO:0018189: pyrroloquinoline quinone biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |