Genome Property Definition Page
Accession | GenProp0145 | |
Name | histidine degradation to glutamate | |
Type | PATHWAY | |
Description | This pathway is involved in histidine utilization system (hut). HutP is the first gene in the hut operon encoding the hutHUIG operator and a positive regulator of the operon, activated allostatically in the presence of L-histidine. HutC represses the histidine utilization by binding the regulatory sites for the hutHUIG and hutF the divergent.In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate have two other possible alternatives. One is involved with the tetrahydrofolate (THF) dependent glutamate formiminotransferase interconverting L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia - part of the process of regenerating THF. The other alternative is involved with hutF (formiminoglutamate hydrolase). | |
JCVI Role | Amino acids and amines | |
Parent Property | GenProp0734: amino acid catabolism | |
Literature References |
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Web References | KEGG: Histidine Metabolism IUBMB: Histidine Catabolism | |
Gene Ontology Term | GO:0006548: histidine catabolic process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
histidine ammonia-lyase (hutH) | 1 | YES | TIGR01225 (HMM): histidine ammonia-lyase | GO:0006548: histidine catabolic process |
urocanate hydratase (hutU) | 2 | YES | TIGR01228 (HMM): urocanate hydratase | GO:0006548: histidine catabolic process |
imidazolonepropionase (hutI) | 3 | YES | TIGR01224 (HMM): imidazolonepropionase | GO:0006548: histidine catabolic process |
formimidoylglutamate deiminase/formiminoglutamase/glu-formyltransferase | 4/4A | YES | TIGR01227 (HMM): formimidoylglutamase TIGR02022 (HMM): formiminoglutamate deiminase TIGR02024 (HMM): glutamate formiminotransferase | GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process |
formylglutamate deformylase/formiminoglutamase/glu-formyltransferase | 4/4B | YES | TIGR01227 (HMM): formimidoylglutamase TIGR02017 (HMM): N-formylglutamate deformylase TIGR02024 (HMM): glutamate formiminotransferase | GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process GO:0006548: histidine catabolic process |
histidine utilization repressor (hutC) | reg | NO | TIGR02018 (HMM): histidine utilization repressor |
Parent Properties
Accession | Name |
---|---|
GenProp0734 | amino acid catabolism |
Sibling Properties
Accession | Name |
---|---|
GenProp0139 | degradation of tyrosine via homogentisate |
GenProp0309 | arginine catabolism to glutamate via arginine succinyltransferase (AST) |
GenProp0456 | attenuation system: tryptophanase |
GenProp0639 | arginine degradation via citrulline, ATP-generating |
GenProp0659 | tryptophan degradation to anthranilate |