Genome Property Definition Page
| Accession | GenProp0055 |
| Name | polyhydroxyalkanoic acids |
| Type | SYSTEM |
| Description | Polyhydroxyalkanoic acids (PHAs) are high molecular weight carbon and energy storage molecules, linear polymers in which the monomeric units have the form -[O-CHR(CH2)xCO]-. The aliphatic polyesters occur in inclusion bodies in various bacteria and archaea. The most common form is polyhydroxybutyric acid, -[0-CHCH3-CH2-CO]-. Typical biosynthetic enzymes include ketothiolases, reductases, and PHA synthases. Additional proteins may include small PHA inclusion body-associated proteins. Typical gene symbols include pha (phb for polyhydroxybutyrate) A (ketothiolase), B (reductase), C (synthase), Z (depolymerase), E (second subunit of heterodimeric-type PHA synthase), R, and Q. |
| Parent Property | GenProp0142: catabolism GenProp0157: storage polymer systems GenProp0186: storage and structural polymer biosynthesis |
| Gene Ontology Term | GO:0006112: energy reserve metabolic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| acetoacetyl-CoA reductase | 2 | YES | TIGR01829 (HMM): acetoacetyl-CoA reductase | |
| 3-hydroxybutyrate dehydrogenase | 3-HB-DH | NO | TIGR01963 (HMM): 3-hydroxybutyrate dehydrogenase | |
| poly(R)-hydroxyalkanoic acid synthase | PHA_syn | YES | TIGR01838 (HMM): poly(R)-hydroxyalkanoic acid synthase, class I TIGR01839 (HMM): poly(R)-hydroxyalkanoic acid synthase, class II TIGR01836 (HMM): poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit TIGR01834 (HMM): poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit | |
| esterase, PHB depolymerase family, or polyhydroxyalkanoate depolymerase, intracellular | depolase | YES | TIGR01840 (HMM): esterase, PHB depolymerase family TIGR01849 (HMM): polyhydroxyalkanoate depolymerase, intracellular TIGR02240 (HMM): poly(3-hydroxyalkanoate) depolymerase | GO:0006112: energy reserve metabolic process |
| phasin family protein or poly(hydroxyalcanoate) granule-associated protein | gransurf | YES | TIGR01841 (HMM): phasin family protein TIGR01837 (HMM): poly(hydroxyalkanoate) granule-associated protein TIGR01985 (HMM): phasin TIGR02809 (HMM): phasin family protein | GO:0006112: energy reserve metabolic process GO:0006112: energy reserve metabolic process |
| predicted granule component | grn_prd | NO | TIGR02610 (HMM): putative polyhydroxyalkanoic acid system protein | GO:0006112: energy reserve metabolic process |
| PHA inclusion probable storage protein PhaP | incl_P | NO | TIGR02131 (HMM): polyhydroxyalkanoic acid inclusion protein PhaP | GO:0006112: energy reserve metabolic process |
| regulatory subunit of PHA synthase | reg_sub | NO | TIGR02132 (HMM): polyhydroxyalkanoic acid synthase, PhaR subunit | GO:0006112: energy reserve metabolic process |
| polyhydroxyalkanoate synthesis repressor PhaR | repress | YES | TIGR01848 (HMM): polyhydroxyalkanoate synthesis repressor PhaR | |
| Thiolase, N-terminal domain | thiolase | NO |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0142 | catabolism |
| GenProp0157 | storage polymer systems |
| GenProp0186 | storage and structural polymer biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0141 | galactose-6-phosphate degradation via tagatose-6-phosphate |
| GenProp0156 | cyanophycin-like storage polymers |
| GenProp0168 | glycogen system |
| GenProp0210 | phenylacetic acid catabolism |
| GenProp0231 | 4-hydroxyphenylacetate degradation |
| GenProp0233 | GABA utilization |
| GenProp0238 | 2-aminoethylphosphonate catabolism to acetaldehyde |
| GenProp0239 | propionyl-CoA catabolism |
| GenProp0241 | phosphonate catabolism |
| GenProp0271 | trehalose utilization |
| GenProp0272 | pyruvate fermentation to acetoin |
| GenProp0273 | protocatechuate degradation to beta-ketoadipate |
| GenProp0283 | beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA |
| GenProp0294 | ethanolamine degradation proteinaceous organelle |
| GenProp0457 | rhamnose catabolism |
| GenProp0458 | fucose catabolism |
| GenProp0461 | utilization of deoxynucleosides |
| GenProp0653 | ectoine catabolism |
| GenProp0674 | malonate decarboxylase |
| GenProp0686 | allantoin catabolism to glyoxalate and urea |
| GenProp0687 | allantoin catabolism to oxamate and carbamoyl-phosphate |
| GenProp0688 | urate catabolism to allantoin |
| GenProp0691 | glycolysis |
| GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
| GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
| GenProp0700 | purine catabolism via urate, xanthine and allantoin |
| GenProp0702 | benzoyl-CoA reductase |
| GenProp0703 | 4-hydroxybenzoyl-CoA reductase |
| GenProp0706 | cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway |
| GenProp0708 | catechol meta-cleavage pathway |
| GenProp0709 | benzoate catabolism BoxABC pathway |
| GenProp0711 | catechol ortho-cleavage upper pathway |
| GenProp0714 | galactarate utilization via tartronate semi-aldehyde |
| GenProp0715 | galactarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0716 | glucarate utilization via tartronate semi-aldehyde |
| GenProp0717 | glucarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0718 | oxalate degradation |
| GenProp0734 | amino acid catabolism |
| GenProp0749 | choline sulfate utilization |
| GenProp0760 | putrescine degradation to GABA via gamma-glutamylation |
| GenProp0763 | nicotinate fermentation to pyruvate and propionate |
| GenProp0810 | encapsulin proteinaceous organelle |
| GenProp0813 | pyrimidine utilization operon, RutABCDEFGR |
| GenProp0902 | quinohemoprotein amine dehydrogenase |
| GenProp1071 | myo-inositol catabolism |
| GenProp1072 | cyanase system |
| GenProp1076 | choline TMA-lyase system |
| GenProp0840 | polyphosphate kinase/exopolyphosphatase system |
| GenProp0158 | peptidoglycan(murein) biosynthesis |
| GenProp0183 | dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0652 | exopolysaccharide biosynthesis, exosortase A-associated |
| GenProp0655 | exopolysaccharide biosynthesis, exosortase B-associated |
| GenProp0658 | cellulose biosynthesis |
| GenProp0793 | CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine |
| GenProp0822 | poly(gamma-glutamic acid) biosynthesis |
| GenProp0906 | poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type |
| GenProp0907 | poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type |